The talpid2 chick limb has weak polarizing activity and can respond to retinoic acid and polarizing zone signal
نویسندگان
چکیده
منابع مشابه
The zone of polarizing activity: evidence for a role in normal chick limb morphogenesis.
When an impermeable barrier is placed so as to divide the early chick limb-bud into anterior and posterior parts then development continues only on one side of the barrier. The detailed results are inconsistent with mosaic development. They can readily be explained by supposing that pattern is specified by the concentration of a diffusible morphogen controlled by the zone of polarizing activity...
متن کاملRetinoic acid signaling is required during early chick limb development.
In the chick limb bud, the zone of polarizing activity controls limb patterning along the anteroposterior and proximodistal axes. Since retinoic acid can induce ectopic polarizing activity, we examined whether this molecule plays a role in the establishment of the endogenous zone of polarizing activity. Grafts of wing bud mesenchyme treated with physiologic doses of retinoic acid had weak polar...
متن کاملRetinoic acid induces a pattern of digits in anterior half wing buds that lack the zone of polarizing activity.
Wing buds whose posterior half is excised, develop into wings lacking distal structures. However, such experimentally generated preaxial half wing buds can be rescued by implanting a retinoic-acid-releasing bead at their anterior margin. The polarity of the pattern that originates from preaxial half wing buds is reversed. For example, instead of a 234 digit pattern typical for normal wings, the...
متن کاملRetinoic acid and chick limb bud development.
The chick limb bud is a powerful experimental system in which to study pattern formation in vertebrate embryos. Exogenously applied retinoic acid, a vitamin A derivative, can bring about changes in pattern and, on several grounds, is a good candidate for an endogenous morphogen. As such, the local concentration of retinoic acid might provide cells with information about their position in relati...
متن کاملDistribution of polarizing activity and potential for limb formation in mouse and chick embryos and possible relationships to polydactyly.
A central feature of the tetrapod body plan is that two pairs of limbs develop at specific positions along the head-to-tail axis. However, the potential to form limbs in chick embryos is more widespread. This could have implications for understanding the basis of limb abnormalities. Here we extend the analysis to mouse embryos and examine systematically the potential of tissues in different reg...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 1992
ISSN: 1058-8388
DOI: 10.1002/aja.1001930107